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Successful treatment of autoimmune lymphoproliferative syndrome and refractory autoimmune thrombocytopenic purpura with a reduced intensity conditioning stem cell transplantation followed by donor lymphocyte infusion

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References

  1. Worth A, Thrasher AJ, Gaspar HB . Autoimmune lymphoproliferative syndrome: molecular basis of disease and clinical phenotype. Br J Haematol 2006; 133: 124–140.

    Article  CAS  PubMed  Google Scholar 

  2. Straus SE, Sneller M, Lenardo MJ, Puck JM, Strober W . An inherited disorder of lymphocyte apoptosis: the autoimmune lymphoproliferative syndrome. Ann Intern Med 1999; 130: 591–601.

    Article  CAS  PubMed  Google Scholar 

  3. Sneller MC, Wang J, Dale JK, Strober W, Middelton LA, Choi Y et al. Clincal, immunologic, and genetic features of an autoimmune lymphoproliferative syndrome associated with abnormal lymphocyte apoptosis. Blood 1997; 89: 1341–1348.

    CAS  PubMed  Google Scholar 

  4. Rieux-Laucat F, Le Deist F, Fischer A . Autoimmune lymphoproliferative syndromes: genetic defects of apoptosis pathways. Cell Death Differ 2003; 10: 124–133.

    Article  CAS  PubMed  Google Scholar 

  5. Poppema S, Maggio E, van den Berg A . Development of lymphoma in Autoimmune Lymphoproliferative Syndrome (ALPS) and its relationship to Fas gene mutations. Leuk Lymphoma 2004; 45: 423–431.

    Article  CAS  PubMed  Google Scholar 

  6. Chakraverty R, Peggs K, Chopra R, Milligan DW, Kottaridis PD, Verfuerth S et al. Limiting transplantation-related mortality following unrelated donor stem cell transplantation by using a nonmyeloablative conditioning regimen. Blood 2002; 99: 1071–1078.

    Article  CAS  PubMed  Google Scholar 

  7. Sleight BJ, Prasad VS, DeLaat C, Steele P, Ballard E, Arceci RJ et al. Correction of autoimmune lymphoproliferative syndrome by bone marrow transplantation. Bone Marrow Transplant 1998; 22: 375–380.

    Article  CAS  PubMed  Google Scholar 

  8. Benkerrou M, Le Deist F, de Villartay JP, Caillat-Zucman S, Rieux-Laucat F, Jabado N et al. Correction of Fas (CD95) deficiency by haploidentical bone marrow transplantation. Eur J Immunol 1997; 27: 2043–2047.

    Article  CAS  PubMed  Google Scholar 

  9. Vacek MM, Schaffer AA, Davis J, Fischer RE, Dale JK, Adams S et al. HLA B44 is associated with decreased severity of autoimmune lymphoproliferative syndrome in patients with CD95 defects (ALPS type Ia). Clin Immunol 2006; 118: 59–65.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Haematology, Royal Free Hospital, London, UK

    M N Dimopoulou, S Gandhi, R Chakraverty, A Fielding, S Mackinnon & P D Kottaridis

  2. Cambridge Blood Centre, Cambridge, UK

    C Ghevaert

  3. Department of Immunology, Royal Free Hospital, London, UK

    D Webster

Authors
  1. M N Dimopoulou
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  2. S Gandhi
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  3. C Ghevaert
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  4. R Chakraverty
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  5. A Fielding
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  6. D Webster
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  7. S Mackinnon
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  8. P D Kottaridis
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Correspondence to P D Kottaridis.

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Dimopoulou, M., Gandhi, S., Ghevaert, C. et al. Successful treatment of autoimmune lymphoproliferative syndrome and refractory autoimmune thrombocytopenic purpura with a reduced intensity conditioning stem cell transplantation followed by donor lymphocyte infusion. Bone Marrow Transplant 40, 605–606 (2007). https://doi.org/10.1038/sj.bmt.1705775

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