Summary:
Bone marrow cells have been suggested to have multilineage plasticity including formation of cardiac tissue. We have established a cardiomyogenic (CMG) cell line from mouse bone marrow stromal cells that can be induced to differentiate into cardiomyocytes in vitro by 5-azacytidine treatment. A number of lines of evidence confirm the cardiomyocyte characteristics of CMG cells.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Leor J, Patterson M, Quinones MJ et al. Transplantation of fetal myocardial tissue into the infarcted myocardium of rat. A potential method for repair of infarcted myocardium? Circulation 1996; 94 (Suppl II): 332–336.
Prockop DJ . Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 1997; 276: 71–74.
Makino S, Fukuda K, Miyoshi S et al. Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest 1999; 103: 697–705.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fukuda, K. Use of adult marrow mesenchymal stem cells for regeneration of cardiomyocytes. Bone Marrow Transplant 32 (Suppl 1), S25–S27 (2003). https://doi.org/10.1038/sj.bmt.1703940
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1703940
- Springer Nature Limited
Keywords
This article is cited by
-
Genome-wide methylome pattern predictive network analysis reveal mesenchymal stem cell’s propensity to undergo cardiovascular lineage
3 Biotech (2022)
-
Cardiac Differentiation of Mesenchymal Stem Cells: Impact of Biological and Chemical Inducers
Stem Cell Reviews and Reports (2021)
-
Multipotent mesenchymal stromal cells play critical roles in hepatocellular carcinoma initiation, progression and therapy
Molecular Cancer (2018)
-
Is the mesenchymal stem cell a new hope for the management of COPD?
Current Respiratory Care Reports (2014)
-
Zellbasierte Therapie der Belastungsinkontinenz
Der Urologe (2014)