Abstract
A 37-year-old man developed delayed non-infectious lung disease after undergoing bone marrow transplantation (BMT) for acute myeloid leukaemia. Over a 15-month period, the progression of morphologic changes from cellular interstitial pneumonia to bronchiolitis obliterans organizing pneumonia and cicatricial bronchiolitis obliterans was documented. Pulmonary function tests, high-resolution CT, bronchoalveolar lavage, lung biopsy and extensive microbiological studies were used as diagnostic tools either at onset and during the follow-up. This represents the first reported case in which a model – supported by longitudinal biopsy results – for the evolution of histologic lesions toward bronchiolitis obliterans after BMT is suggested; therapeutic implications are discussed.
Bone Marrow Transplantation (2001) 28, 1167–1170.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Palmas A, Tefferi A, Myers JL et al. Late-onset non-infectious pulmonary complications after allogeneic bone marrow transplantation Br J Haematol 1998 100: 680–687
Schwarer AP, Hughes JM, Trotman-Dickenson B et al. A chronic pulmonary syndrome associated with graft-versus-host disease after allogeneic bone marrow transplantation Transplantation 1992 54: 1002–1008
Duncker C, Dohr D, von Harsdorf S et al. Non-infectious lung complications are closely associated with chronic graft-versus-host disease: a single center study of incidence, risk factors and outcome Bone Marrow Transplant 2000 25: 1263–1268
Sanchez J, Torres A, Serrano A et al. Long term follow-up of immunosuppressive treatment for obstructive airways disease after allogeneic bone marrow transplantation Bone Marrow Transplant 1997 20: 403–408
Trisolini R, Stanzani M, Lazzari Agli L et al. Delayed non-infectious lung disease in allogeneic bone marrow transplant recipients Sarcoidosis Vasc Diffuse Lung Dis 2001 18: 75–84
Poletti V, Salvucci M, Zanchini R et al. The lung as a target in haematologic patients Haematology 2000 85: 855–864
Yousem SA . The histological spectrum of pulmonary graft-versus-host disease in bone marrow transplant recipients Hum Pathol 1995 26: 668–675
Leblond V, Zouabi H, Sutton L et al. Late CD8+ lymphocytic alveolitis after allogeneic bone marrow transplantation and chronic graft-versus-host disease Am J Respir Crit Care Med 1994 150: 1056–1061
Poletti V, Cancellieri A, Zompatori M . The clinical spectrum of adult bronchiolitis Sarcoidosis Vasc Diffuse Lung Dis 1999 16: 183–196
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Trisolini, R., Bandini, G., Stanzani, M. et al. Morphologic changes leading to bronchiolitis obliterans in a patient with delayed non-infectious lung disease after allogeneic bone marrow transplantation. Bone Marrow Transplant 28, 1167–1170 (2001). https://doi.org/10.1038/sj.bmt.1703303
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1703303
- Springer Nature Limited
Keywords
This article is cited by
-
Correlation of lung abnormalities on high-resolution CT with clinical graft-versus-host disease after allogeneic versus autologous bone marrow transplantation in children
Pediatric Radiology (2008)
-
High-dose corticosteroid therapy for bronchiolitis obliterans after bone marrow transplantation in children
Bone Marrow Transplantation (2005)