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Inappropriate antidiuretic hormone secretion after high-dose thiotepa

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Abstract

High-dose thiotepa has been successfully included in a variety of conditioning regimens for stem cell transplantation in hematological and solid neoplasms. Toxicity of high-dose thiotepa mainly manifests as profound myeloablation and some degree of liver damage. We report a case of inappropriate secretion of antidiuretic hormone (SIADH) in a patient with primary CNS lymphoma who underwent therapy with high-dose thiotepa.

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Sica, S., Cicconi, S., Sorà, F. et al. Inappropriate antidiuretic hormone secretion after high-dose thiotepa. Bone Marrow Transplant 24, 571–572 (1999). https://doi.org/10.1038/sj.bmt.1701922

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  • DOI: https://doi.org/10.1038/sj.bmt.1701922

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