Abstract
This case describes a 16-year-old woman treated successfully by a bone marrow transplant from her HLA-identical brother for refractory acquired pure red cell aplasia. Conditioning was as for severe aplastic anaemia with cyclophosphamide 4 × 50 mg/kg and antithymocyte globulin. Complete donor type engraftment at 3 months reversed to full autologous reconstitution at 2 years with normal haemopoiesis. The potential implications on pathogenesis of the disease as well as on treatment of autoimmune disorders by stem cell transplantation are discussed.
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Müller, B., Tichelli, A., Passweg, J. et al. Successful treatment of refractory acquired pure red cell aplasia (PRCA) by allogeneic bone marrow transplantation. Bone Marrow Transplant 23, 1205–1207 (1999). https://doi.org/10.1038/sj.bmt.1701785
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1701785
- Springer Nature Limited
Keywords
This article is cited by
-
Haematopoietic SCT in autoimmune diseases in children: rationale and new perspectives
Bone Marrow Transplantation (2008)
-
Reduced intensity conditioning bone marrow transplantation for pure red cell aplasia: successful outcome but difficult post transplant course
Bone Marrow Transplantation (2005)
-
Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: Getting closer to a cure?
International Journal of Hematology (2002)
-
Allogeneic stem cell transplantation for Evans syndrome
Bone Marrow Transplantation (2001)
-
Recovery of erythropoiesis following allogeneic bone marrow transplantation for chronic lymphocytic leukaemia-associated pure red cell aplasia
Bone Marrow Transplantation (2001)