Abstract
The clinical course of chronic myeloid leukaemia (CML) is characterised by a chronic phase followed by an acute phase or blast crisis. Lymphoid transformation accounts for 20–30% of such events, with the majority of cases being of B cell origin. Extramedullary transformation occurs in approximately 10% of cases. We report a case of T cell lymphoblastic transformation in CML presenting as an extramedullary mass after allogeneic stem cell transplant. This case supports the growing evidence that CML arises in the pluripotent stem cell.
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Kell, J., Booth, M., Jones, B. et al. Extramedullary T lymphoblastic transformation of chronic myeloid leukaemia occurring after double allogeneic transplantation. Bone Marrow Transplant 22, 813–816 (1998). https://doi.org/10.1038/sj.bmt.1701430
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DOI: https://doi.org/10.1038/sj.bmt.1701430
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