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Gastrointestinal perforation early after peripheral blood stem cell transplantation for AL amyloidosis

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Abstract

The morbidity and mortality of AL amyloidosis is caused by the deposition of Ig light chains as amyloid protein in vital organs. With conventional therapy median survival of patients with AL amyloidosis is 10–14 months. With high-dose chemotherapy clinical remissions of organ-specific disease have been reported. Here, we present a patient with high-risk AL amyloidosis who was given high-dose therapy and a peri- pheral blood stem cell transplant. Four days later she died of gastrointestinal perforation due to amyloid infiltrations.

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Authors and Affiliations

  1. Department of Medicine I, Bone Marrow Transplantation Unit, University of Vienna, Austria

    A Schulenburg, P Kalhs, E Reiter & HT Greinix

  2. Department of Pathology, University of Vienna, Austria

    G Oberhuber

  3. Department of Medicine III, University of Vienna, Austria

    W Base

Authors
  1. A Schulenburg
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  2. P Kalhs
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  3. G Oberhuber
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  4. E Reiter
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  5. W Base
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  6. HT Greinix
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Schulenburg, A., Kalhs, P., Oberhuber, G. et al. Gastrointestinal perforation early after peripheral blood stem cell transplantation for AL amyloidosis. Bone Marrow Transplant 22, 293–295 (1998). https://doi.org/10.1038/sj.bmt.1701330

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  • DOI: https://doi.org/10.1038/sj.bmt.1701330

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