Abstract
An 8.5-month-old boy with Wiskott–Aldrich syndrome received a sibling matched bone marrow transplant from his healthy non-identical twin brother. The donor had primary human herpes virus 6 (HHV-6) infection around the time of bone marrow donation. The recipient had hepatitis in the first week and then developed fever and rash on day 18. Skin biopsy was shown to have HHV-6 antigen and his peripheral blood leukocytes were HHV-6 DNA positive. He engrafted on day 18 but the ANC dropped from 5.5 × 109/l (day 23) to 0.48 × 109/l (day 34) with persistent HHV-6 DNAemia. Bone marrow on day 35 was positive for HHV-6 DNA. He was treated with G-CSF and ganciclovir with good response. He later had pneumonitis which was treated empirically with foscarnet, ceftazidime and clarithromycin.
Access this article
We’re sorry, something doesn't seem to be working properly.
Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lau, Y., Peiris, M., Chan, G. et al. Primary human herpes virus 6 infection transmitted from donor to recipient through bone marrow infusion. Bone Marrow Transplant 21, 1063–1066 (1998). https://doi.org/10.1038/sj.bmt.1701230
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1701230
- Springer Nature Limited
Keywords
This article is cited by
-
Human herpesvirus 6 (HHV6) infection
The Indian Journal of Pediatrics (2004)
-
Human herpesvirus 6 and human herpesvirus 7: Emerging pathogens in transplant patients
International Journal of Hematology (2002)
-
Successful mismatched sibling cord blood transplant in Hb Bart's disease
Bone Marrow Transplantation (2001)