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Testicular relapse of acute promyelocytic leukemia after allogeneic BMT

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Abstract

After treatment of acute leukemia (typically ALL and the monocytic variants of AML), relapse may occur at sites other than the marrow. Isolated extramedullary relapse of acute promyelocytic leukemia (APL) however, is rare. We describe such an event in a man who underwent allogeneic BMT for APL in second relapse and 4 years later presented with testicular relapse. The marrow was morphologically and cytogenetically normal, but RT-PCR analysis revealed the specific PML/RAR chimeric RNA transcript.

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Authors and Affiliations

  1. Leukemia/Bone Marrow Transplantation Program of British Columbia: Divisions of Hematology, British Columbia Cancer Agency, Vancouver Hospital and Health Sciences Centre and the University of British Columbia, Vancouver, Canada

    DL Forrest, WB Benny & MJ Barnett

  2. Leukemia/Bone Marrow Transplantation Program of British Columbia: Divisions of Hematopathology, British Columbia Cancer Agency, Vancouver Hospital and Health Sciences Centre and the University of British Columbia, Vancouver, Canada

    BI Dalal & SC Naiman

  3. Leukemia/Bone Marrow Transplantation Program of British Columbia: Divisions of Laboratory Medicine, British Columbia Cancer Agency, Vancouver Hospital and Health Sciences Centre and the University of British Columbia, Vancouver

    DE Horsman

  4. Greater Victoria Hospital Society, Victoria, British Columbia, Canada

    BR Berry, MI Parslow & CP Singh

Authors
  1. DL Forrest
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  2. BI Dalal
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  3. SC Naiman
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  4. DE Horsman
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  5. BR Berry
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  6. MI Parslow
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  7. CP Singh
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  8. WB Benny
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  9. MJ Barnett
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Forrest, D., Dalal, B., Naiman, S. et al. Testicular relapse of acute promyelocytic leukemia after allogeneic BMT. Bone Marrow Transplant 20, 689–690 (1997). https://doi.org/10.1038/sj.bmt.1700948

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  • DOI: https://doi.org/10.1038/sj.bmt.1700948

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