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Micro- and nanorobots for biofilm eradication

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Micro- and nanorobots present a promising approach for navigating within the body and eliminating biofilm infections. Their motion can be remotely controlled by external fields and tracked by clinical imaging. They can mechanically disrupt the biofilm matrix and kill the dormant bacterial cells synergistically, thereby improving the effectiveness of biofilm eradication.

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Fig. 1: Schematic diagram of MNR platforms and the potential medical procedure, mechanisms and challenges to combat biofilm infection inside the human body.

References

  1. Choi, V., Rohn, J. L., Stoodley, P., Carugo, D. & Stride, E. Drug delivery strategies for antibiofilm therapy. Nat. Rev. Microbiol. 21, 555–572 (2023).

    Article  Google Scholar 

  2. Stewart, P. S. & Costerton, J. W. Antibiotic resistance of bacteria in biofilms. Lancet 358, 135–138 (2001).

    Article  Google Scholar 

  3. Nelson, B. J. & Pané, S. Delivering drugs with microrobots. Science 382, 1120–1122 (2023).

    Article  Google Scholar 

  4. Hwang, G. et al. Catalytic antimicrobial robots for biofilm eradication. Sci. Robot. 4, eaaw2388 (2019).

    Article  Google Scholar 

  5. Dong, Y. et al. Endoscope-assisted magnetic helical micromachine delivery for biofilm eradication in tympanostomy tube. Sci. Adv. 8, eabq8573 (2022).

    Article  Google Scholar 

  6. Yang, L. et al. Autonomous environment-adaptive microrobot swarm navigation enabled by deep learning-based real-time distribution planning. Nat. Mach. Intell. 4, 480–493 (2022).

    Article  Google Scholar 

  7. Boudarel, H., Mathias, J. D., Blaysat, B. & Grédiac, M. Towards standardized mechanical characterization of microbial biofilms: analysis and critical review. npj Biofilms Microbiomes 4, 17 (2018).

    Article  Google Scholar 

  8. Wong, L. L. et al. Microbial biofilms are shaped by the constant dialogue between biological and physical forces in the extracellular matrix. Environ. Microbiol. 25, 199–208 (2023).

    Article  Google Scholar 

  9. Nijjer, J. et al. Biofilms as self-shaping growing nematics. Nat. Phys. 19, 1936–1944 (2023).

    Article  Google Scholar 

  10. Gu, H., Lee, S. W., Carnicelli, J., Zhang, T. & Ren, D. Magnetically driven active topography for long-term biofilm control. Nat. Commun. 11, 2211 (2020).

    Article  Google Scholar 

Download references

Acknowledgements

L.Z. thanks the support by the Hong Kong Research Grants Council (RGC) Research Fellow Scheme (project no. RFS2122-4S03) and the Strategic Topics Grant (project no. STG1/E-401/23-N). We also thank the support from the Multi-scale Medical Robotics Centre (MRC), InnoHK, at the Hong Kong Science Park and the SIAT-CUHK Joint Laboratory of Robotics and Intelligent Systems.

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Authors and Affiliations

  1. Department of Mechanical and Automation Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China

    Bonan Sun & Li Zhang

  2. Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore, Singapore

    Staffan Kjelleberg

  3. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore

    Joseph J. Y. Sung

  4. Department of Surgery, The Chinese University of Hong Kong, Hong Kong SAR, China

    Li Zhang

Authors
  1. Bonan Sun
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  2. Staffan Kjelleberg
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  3. Joseph J. Y. Sung
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  4. Li Zhang
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Contributions

B.S. and L.Z. drafted the manuscript. S.K., J.J.Y.S. and L.Z. reviewed and edited the manuscript.

Corresponding authors

Correspondence to Staffan Kjelleberg, Joseph J. Y. Sung or Li Zhang.

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The authors declare no competing interests.

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Sun, B., Kjelleberg, S., Sung, J.J.Y. et al. Micro- and nanorobots for biofilm eradication. Nat Rev Bioeng 2, 367–369 (2024). https://doi.org/10.1038/s44222-024-00176-3

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  • DOI: https://doi.org/10.1038/s44222-024-00176-3

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