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CRISPR quality control on a chip

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Combining the precision of CRISPR’s DNA searching ability with the speed and scalability of electronics, we have developed an ‘electronic DNA search engine’, called a CRISPR–Chip, which not only enables DNA detection without amplification, but also showcases the untapped potential of merging molecular biology with nanomaterial electronics. Here, we discuss highlights and challenges on the journey from the initial idea to the commercialization of the CRISPR–Chip.

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Fig. 1: CRISPR–Chip.

References

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Acknowledgements

We acknowledge R. Bundy and M. Heltzen for contributions towards manuscript preparation. The CRISPR–Chip work was supported by discretionary funds to K.A. and National Science Foundation (NSF) award 2048283, National Institutes of Health (NIH) 1R01HL161361 and Cardea Service agreement to the Aran Lab.

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Authors and Affiliations

  1. Shu Chien-Gene Lay Department of Bioengineering, Jacobs School of Engineering, University of California, San Diego, San Diego, CA, USA

    Kiana Aran

  2. Department of Medicine, Division of Geriatrics, Gerontology & Palliative Care, School of Medicine, University of California, San Diego, San Diego, CA, USA

    Kiana Aran

  3. Cardea bio (a part of Paragraf US), San Diego, CA, USA

    Kiana Aran & Brett R. Goldsmith

  4. CRISPR QC, San Diego, USA

    Kiana Aran

Authors
  1. Kiana Aran
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  2. Brett R. Goldsmith
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Contributions

K.A. and B.R.G. prepared the manuscript.

Corresponding author

Correspondence to Kiana Aran.

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Competing interests

K.A. is a co-founder of Cardea and CRISPR QC. B.R.G. is a co-founder of Cardea.

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Related links

Startup to commercialize the CRISPR–Chip: https://communities.springernature.com/posts/crispr-graphene-enabled-gene-detection

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Aran, K., Goldsmith, B.R. CRISPR quality control on a chip. Nat Rev Bioeng 2, 194–195 (2024). https://doi.org/10.1038/s44222-024-00159-4

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  • DOI: https://doi.org/10.1038/s44222-024-00159-4

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