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Clinical translation of radiotheranostics for precision oncology

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Radiotheranostics combines disease-specific molecular imaging and radionuclide therapy. We present new and promising targets, tracers and isotopes for radiotheranostics and outline the road to clinical translation of the 177Lu–LNC1004 radiopharmaceutical, which has recently been approved by the US Food and Drug Administration (FDA) for a phase I clinical trial.

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Correspondence to Jingjing Zhang or Xiaoyuan Chen.

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Competing interests

X.C. is the co-founder and CTO of Yantai LNC Biotechnology. J.Z. is the CMO of Yantai LNC Biotechnology. The other authors declare no competing interests.

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US $5.32 billion in 2022 with a compound annual growth rate of about 10.7% to reach US $12.18 billion by 2030: https://www.databridgemarketresearch.com/reports/global-radiopharmaceuticals-market

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Zhang, J., Zhao, T., Jakobsson, V. et al. Clinical translation of radiotheranostics for precision oncology. Nat Rev Bioeng 1, 612–614 (2023). https://doi.org/10.1038/s44222-023-00106-9

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