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Cardiac renewal

PD-1–PD-L1 immunomodulatory pathway regulates cardiac regeneration

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Adult hearts have inherently limited regenerative capabilities, such that injury results in lasting damage. The situation is different in neonatal mouse hearts, however, where a new study reveals a role for the immunomodulatory PD-1–PD-L1 pathway in regulating regeneration after injury.

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Fig. 1: Immune checkpoint modulators and cardiac regeneration.

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Acknowledgements

J.M. is supported by National Institutes of Health grants R01HL141466, R01HL155990, R01HL156021, R01HL160688 and R01HL170038. G.N.H. is supported by National Institutes of Health grants R01 HL157280 and R01 HL138456, Tobacco-Related Disease Research Program award P0558275, and American Heart Association Established Investigator award 23EIA1039425. J.Q. is supported by UCSF Catalyst Award 2024 and AHA’s Second Century Early Faculty Independence Award 24SCEFIA1246915.

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Authors and Affiliations

  1. Section of Cardio-Oncology & Immunology, Department of Medicine, University of California, San Francisco (UCSF), San Francisco, CA, USA

    Juan Qin & Javid Moslehi

  2. Cardiovascular Research Institute (CVRI), University of California, San Francisco (UCSF), San Francisco, CA, USA

    Juan Qin, Guo N. Huang & Javid Moslehi

  3. Department of Physiology, University of California, San Francisco (UCSF), San Francisco, CA, USA

    Guo N. Huang

Authors
  1. Juan Qin
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  2. Guo N. Huang
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  3. Javid Moslehi
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Correspondence to Javid Moslehi.

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Competing interests

J.M. has provided consulting or advisory roles for Pfizer, Novartis, Bristol-Myers Squibb, Deciphera, Takeda, AstraZeneca, Regeneron, Myovant, Kurome Therapeutics, Kiniksa Pharmaceuticals, Daiichi Sankyo, BeiGene, IQVIA, AskBio, Bitterroot Bio, Repare Therapeutics and Cytokinetics. J.M. is a co-inventor of a patent related to the use of abatacept in the treatment of ICI-myocarditis. J.Q. and G.N.H. declare no competing interests.

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Qin, J., Huang, G.N. & Moslehi, J. PD-1–PD-L1 immunomodulatory pathway regulates cardiac regeneration. Nat Cardiovasc Res 3, 410–411 (2024). https://doi.org/10.1038/s44161-024-00461-9

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