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Heart regeneration

Toward drug-induced heart regeneration

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Inhibition of MEIS1–HOXB13 activity by the aminoglycosides neomycin and paromomycin facilitates cardiomyocyte proliferation and heart regeneration.

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Fig. 1: Inhibition of MEIS1–HOXB13 transcription activity via the aminoglycosides neomycin (Neo) and paromomycin (Paro) stimulates cardiomyocyte proliferation and promotes heart regeneration following injury.

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Authors and Affiliations

  1. Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany

    Xuejun Yuan & Thomas Braun

  2. Cardio-Pulmonary Institute (CPI), Bad Nauheim, Frankfurt, Giessen, Germany

    Xuejun Yuan & Thomas Braun

  3. DZHK (German Center for Cardiovascular Research), Partner Site Rhein-Main, Frankfurt am Main, Germany

    Xuejun Yuan & Thomas Braun

Authors
  1. Xuejun Yuan
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  2. Thomas Braun
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Correspondence to Thomas Braun.

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The authors declare no competing interests.

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Yuan, X., Braun, T. Toward drug-induced heart regeneration. Nat Cardiovasc Res 3, 260–261 (2024). https://doi.org/10.1038/s44161-024-00446-8

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