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Taking BETs on cardiomyocyte differentiation

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From Nature Cardiovascular Research

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Motivated by a CRISPR screen, in vitro and in vivo studies identified an essential role for the bromodomain and extraterminal domain (BET) family member BRD4 in the differentiation of second heart field progenitors into cardiomyocytes. Single-cell transcriptomic studies showed that BRD4 deficiency affects a specific subset of cardiac progenitor cells.

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Fig. 1: The role of BRD4 in cardiomyocyte differentiation.

References

  1. Padmanabhan, A. et al. BRD4 (bromodomain-containing protein 4) interacts with GATA4 (GATA binding protein 4) to govern mitochondrial homeostasis in adult cardiomyocytes. Circulation 142, 2338–2355 (2020). This paper shows how BRD4 interacts with tissue-specific transcription factors to mediate cardiomyocyte homeostasis.

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This is a summary of: Padmanabhan, A. et al. A genome-wide CRISPR screen identifies BRD4 as a regulator of cardiomyocyte differentiation. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-024-00431-1 (2024).

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Taking BETs on cardiomyocyte differentiation. Nat Cardiovasc Res 3, 265–266 (2024). https://doi.org/10.1038/s44161-024-00443-x

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