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Tetralogy of Fallot

BLN protein induces cardiac hypertrophy and failure

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From Nature Cardiovascular Research

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BBLN, a protein with predominantly uncharted functions, serves as an instigator of CAMK2D autophosphorylation, leading to subsequent cardiac remodeling and failure in both humans and mice. The induction of BBLN is driven by hypoxia in TOF and/or pressure overload, as evidenced in mouse models.

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Fig. 1: The effect of BBLN on cardiac remodeling.

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Authors and Affiliations

  1. Cardiovascular Genetics, Experimental and Clinical Research Center, Charité – Universitätsmedizin Berlin, Berlin, Germany

    Silke R. Sperling

  2. Department of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, Berlin, Germany

    Silke R. Sperling

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  1. Silke R. Sperling
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Correspondence to Silke R. Sperling.

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Sperling, S.R. BLN protein induces cardiac hypertrophy and failure. Nat Cardiovasc Res 2, 964–965 (2023). https://doi.org/10.1038/s44161-023-00357-0

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