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Clonal hematopoiesis

How clonal hematopoiesis promotes inflammation at a single-cell level

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From Nature Cardiovascular Research

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A method to identify and analyze clonal hematopoiesis in clinical blood samples at single-cell resolution reveals cell-intrinsic and paracrine effects of DNMT3A mutations in circulating monocytes, T cells and natural killer cells in the setting of heart failure.

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Fig. 1: Inflammation triggered by DNMT3A clonal hematopoiesis.

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Authors and Affiliations

  1. Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA

    Nicholas W. Chavkin, Megan A. Evans & Kenneth Walsh

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  1. Nicholas W. Chavkin
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  2. Megan A. Evans
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  3. Kenneth Walsh
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Correspondence to Kenneth Walsh.

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The authors declare no competing interests.

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Chavkin, N.W., Evans, M.A. & Walsh, K. How clonal hematopoiesis promotes inflammation at a single-cell level. Nat Cardiovasc Res 2, 801–802 (2023). https://doi.org/10.1038/s44161-023-00323-w

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