Skip to main content
Log in

The sum of the parts is greater than the whole: current research models for congenital heart disease

  • Comment
  • Published:

From Nature Cardiovascular Research

View current issue Submit your manuscript

Several experimental systems have been used over the past five decades to address important questions in cardiac development and congenital heart disease. Here we discuss the strengths and limitations of available models, and how the use of different models synergistically is needed for a deeper understanding of these complex diseases.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1: Current methods to study CHD.

References

  1. Bodmer, R. Development 118, 719–729 (1993).

    Article  CAS  PubMed  Google Scholar 

  2. Tu, S. et al. Differentiation 84, 4–16 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Gore, A. V. et al. Cold Spring Harb. Perspect. Med. 2, a006684 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Keller, B. B. Am. J. Physiol. Heart Circ. Physiol. 289, H975–H976 (2005).

    Article  CAS  PubMed  Google Scholar 

  5. Furtado, M. B. et al. Differentiation 91, 29–41 (2016).

    Article  CAS  PubMed  Google Scholar 

  6. Chen, H. et al. Development 131, 2219–2231 (2004).

    Article  CAS  PubMed  Google Scholar 

  7. Bruneau, B. G. et al. Cell 106, 709–721 (2001).

    Article  CAS  PubMed  Google Scholar 

  8. Baban, A. et al. Am. J. Med. Genet. A 164A, 3100–3107 (2014).

    Article  PubMed  Google Scholar 

  9. Camacho, P., Fan, H., Liu, H. & He, J.-Q. J. Cardiovasc. Dev. Dis. 3, 30 (2016).

    PubMed  PubMed Central  Google Scholar 

  10. Takahashi, K. et al. Cell 131, 861–872 (2007).

    Article  CAS  PubMed  Google Scholar 

  11. Seok, H., Deng, R., Cowan, D. B. & Wang, D.-Z. Clin. Exp. Pediatr. 64, 269–279 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Rao, K. S., Kameswaran, V. & Bruneau, B. G. Genes Dev. 36, 652–663 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Paige, S. L. et al. Circulation 142, 1605–1608 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  14. Hofbauer, P. et al. Cell 184, 3299–3317 (2021).

    Article  CAS  PubMed  Google Scholar 

  15. Li, H., Brouwer, C. R. & Luo, W. Nat. Commun. 13, 1901 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sean M. Wu.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Samad, T., Wu, S.M. The sum of the parts is greater than the whole: current research models for congenital heart disease. Nat Cardiovasc Res 2, 708–710 (2023). https://doi.org/10.1038/s44161-023-00308-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s44161-023-00308-9

  • Springer Nature Limited

Navigation