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Systemic inflammation

Modelling systemic risk factors in cardiovascular disease using single-cell biology

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From Nature Cardiovascular Research

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The plasma of individuals with atherosclerosis contains cytokines that induce a pathogenic signaling cascade in immune cells. Saracatinib, a dual kinase inhibitor that targets the tyrosine kinases SRC and BCR-ABL, can prevent activation of this phospho-signaling pathway implicated in the pathogenesis of cardiovascular disease.

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Fig. 1: Atheroplasma induces a pathogenic tyrosine phosphorylation-dependent signaling cascade in myeloid cells in CVD.

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Authors and Affiliations

  1. Kennedy Institute, University of Oxford, Oxford, UK

    Claudia Monaco & Lea Dib

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  1. Claudia Monaco
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  2. Lea Dib
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Correspondence to Claudia Monaco.

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The authors have no competing interests.

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Monaco, C., Dib, L. Modelling systemic risk factors in cardiovascular disease using single-cell biology. Nat Cardiovasc Res 2, 496–497 (2023). https://doi.org/10.1038/s44161-023-00285-z

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