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Statins and endothelium

Rescue of EndMT-associated endothelial dysfunction by modulating the YAP pathway

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From Nature Cardiovascular Research

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Statins exert cardiovascular protective effects that are independent of cholesterol lowering. Using endothelial cells derived from induced pluripotent stem cells, Liu et al. show that statins can improve endothelial dysfunction by inhibiting endothelial–mesenchymal transition via epigenetic regulation of the GGTase–RhoA–YAP1–SOX9 signaling pathway.

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Fig. 1: Inhibition of YAP1-mediated chromatin remodeling reverses an EndMT process in iPS-ECs.

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Acknowledgements

This work was supported by grants from the US National Heart, Lung, and Blood Institute (NHLBI; R01HL150877, R01HL156008) the National Research Foundation of Korea (NRF) funded by the Korean government (MSIT) (2020R1A2C3003784, 2020M3A9I4038454), and the Brain Korea 21 FOUR Project for Medical Science, Yonsei University College of Medicine.

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Authors and Affiliations

  1. Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA

    Seongho Bae & Young-sup Yoon

  2. Department of Internal Medicine, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, South Korea

    Cholomi Jung

  3. Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, South Korea

    Cholomi Jung & Young-sup Yoon

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  1. Seongho Bae
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  2. Cholomi Jung
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Correspondence to Young-sup Yoon.

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Y.Y. is a founder and equity holder in Karis Bio. The remaining authors declare no competing interests.

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Bae, S., Jung, C. & Yoon, Ys. Rescue of EndMT-associated endothelial dysfunction by modulating the YAP pathway. Nat Cardiovasc Res 2, 420–422 (2023). https://doi.org/10.1038/s44161-023-00268-0

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