We report an intronic variant of the endothelial angiopoietin receptor TIE2 that is associated with increased gene expression and decreased risk of coronary artery disease. Genetic deletion of Tie2 in hypercholesterolemic mice shows that the Tie2 receptor protects from atherosclerosis by controlling inflammation in the arterial wall.
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References
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This is a summary of: Anisimov, A. et al. The angiopoietin receptor TIE2 is atheroprotective in arterial endothelium. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-023-00224-y (2023).
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Endothelial tyrosine kinase Tie2 counteracts atherosclerosis development. Nat Cardiovasc Res 2, 232–233 (2023). https://doi.org/10.1038/s44161-023-00251-9
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DOI: https://doi.org/10.1038/s44161-023-00251-9
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