Clonal hematopoiesis of indeterminate potential (CHIP) is a blood disorder that can increase the risk of cardiovascular disease. A new study reveals that CHIP driven by somatic mutations in DNA damage repair genes increases the risk of CVD in humans, and provides mechanistic insights in murine models.
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Nagareddy, P.R., Murphy, A.J. TP53 clonal hematopoiesis promotes atherosclerosis. Nat Cardiovasc Res 2, 102–103 (2023). https://doi.org/10.1038/s44161-022-00212-8
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DOI: https://doi.org/10.1038/s44161-022-00212-8
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