Skip to main content
SpringerLink
Log in

Atherosclerosis and platelets

Soluble guanylyl cyclase in platelets keeps atherosclerosis at bay

  • News & Views
  • Published:

From Nature Cardiovascular Research

View current issue Submit your manuscript

The contribution of platelets to atherothrombosis is well established. Accumulating genome-wide association studies have revealed several variants of genes encoding molecules along the nitric oxide (NO)–soluble guanylyl cyclase (sGC)–cyclic guanosine-3′,5′-monophosphate (cGMP) pathway that are associated with increased risk of coronary artery disease; however, the cell types and functional impact of these risk variants remain poorly understood. Mauersberger et al. now demonstrate that platelet-specific knockout of a transcript encoding sGC increased atherosclerosis, whereas pharmacological stimulators of sGC reduced lesions via a paracrine effect of angiopoietin-1 on endothelial cell–leukocyte interactions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Atheroprotective effects of the non-risk sGC allele.

References

  1. Mussbacher, M., Pirabe, A., Brunnthaler, L., Schrottmaier, W. C. & Assinger, A. Front. Physiol. 12, 678362 (2021).

    Article  Google Scholar 

  2. Lievens, D. & von Hundelshausen, P. Thromb. Haemost. 106, 827–838 (2011).

    Article  CAS  Google Scholar 

  3. Muhlestein, J. B. Thromb. Haemost. 103, 71–82 (2010).

    Article  CAS  Google Scholar 

  4. Massberg, S. et al. J. Exp. Med. 196, 887–896 (2002).

    Article  CAS  Google Scholar 

  5. Sim, J. Y. Korean J. Anesthesiol. 58, 4–14 (2010).

    Article  CAS  Google Scholar 

  6. Searles, C. D. Congest. Heart Fail. 8, 142–155 (2002).

    Article  CAS  Google Scholar 

  7. Consortium, C. A. D. et al. Nat. Genet. 45, 25–33 (2013).

    Article  Google Scholar 

  8. Wobst, J. et al. Basic Res. Cardiol. 111, 51 (2016).

    Article  Google Scholar 

  9. Mauersberger, C. et al. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-022-00175-w (2022).

    Article  Google Scholar 

  10. Dangel, O. et al. J. Thromb. Haemost. 8, 1343–1352 (2010).

    Article  CAS  Google Scholar 

  11. Segura-Puimedon, M. et al. Am. J. Pathol. 186, 2220–2231 (2016).

    Article  CAS  Google Scholar 

  12. Tsou, C. Y. et al. Acta Physiol. 210, 799–810 (2014).

    Article  CAS  Google Scholar 

  13. Zhang, G. et al. Blood 118, 3670–3679 (2011).

    Article  CAS  Google Scholar 

  14. Kessler, T. et al. Circulation 136, 476–489 (2017).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

Supported by the US National Institutes of Health (HL115141, HL134849, HL148207, HL148355, HL153356 to M.W.F.) and the American Heart Association (18SFRN33900144 and 20SFRN35200163 to M.W.F.).

Author information

Authors and Affiliations

  1. Department of Medicine, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Anurag Jamaiyar, Jingshu Chen & Mark W. Feinberg

Authors
  1. Anurag Jamaiyar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jingshu Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mark W. Feinberg
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mark W. Feinberg.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Jamaiyar, A., Chen, J. & Feinberg, M.W. Soluble guanylyl cyclase in platelets keeps atherosclerosis at bay. Nat Cardiovasc Res 1, 1124–1126 (2022). https://doi.org/10.1038/s44161-022-00188-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s44161-022-00188-5

  • Springer Nature Limited

This article is cited by

Search

Navigation