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Parenchymal border macrophages

An unnoticed player overseeing CSF flux

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From Nature Cardiovascular Research

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A new study shows that brain-resident parenchymal border macrophages (PBMs) maintain perivascular extracellular matrix composition by the release of matrix metalloproteinases. Depletion of PBMs suppressed glymphatic fluid transport, underscoring their responsibility for perivascular space homeostasis and brain protein clearance.

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Fig. 1: Functions and subtypes of parenchymal border macrophages (PBMs).

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Acknowledgements

We thank D. Xue for expert graphical support. This project has received funding from the Simons Foundation, the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation, the US NIH/NINDS/NCCIH (R01AT012312, R01AT011439 and U19 NS128613) and the Novo Nordisk and Lundbeck Foundations, as well as the US Army Research Office (grant MURI W911NF1910280).

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Authors and Affiliations

  1. Center for Translational Neuromedicine, University of Copenhagen, Copenhagen, Denmark

    Virginia Plá & Maiken Nedergaard

  2. Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA

    Maiken Nedergaard

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  1. Virginia Plá
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  2. Maiken Nedergaard
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Correspondence to Virginia Plá.

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The authors declare no competing interests.

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Plá, V., Nedergaard, M. An unnoticed player overseeing CSF flux. Nat Cardiovasc Res 1, 1114–1115 (2022). https://doi.org/10.1038/s44161-022-00176-9

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