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MYOCARDIAL PERFUSION

Computational insights on coronary artery function

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From Nature Cardiovascular Research

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Collateral arteries may act as natural bypasses that reduce hypoperfusion after a coronary blockage. 3D imaging of neonatal and adult mouse hearts, plus human fetal and diseased adult hearts, is now used to computationally predict flow within the heart, and understand the cardioprotective role of collateral arteries in vivo.

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Fig. 1: Pipeline for image acquisition and computational prediction of flow dynamics in collaterals of the mouse heart after myocardial infarction.

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Authors and Affiliations

  1. Department of Electrical and Computer Engineering, University of Houston, Houston, TX, USA

    David Mayerich

  2. Department of Integrative Physiology, Baylor College of Medicine, Houston, TX, USA

    Joshua D. Wythe

  3. Cardiovascular Research Institute, Baylor College of Medicine, Houston, TX, USA

    Joshua D. Wythe

  4. Center for Organ Renewal and Repair, Baylor College of Medicine, Houston, TX, USA

    Joshua D. Wythe

Authors
  1. David Mayerich
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  2. Joshua D. Wythe
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Correspondence to Joshua D. Wythe.

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D.M. is a founder and stakeholder of Swift Front.

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Mayerich, D., Wythe, J.D. Computational insights on coronary artery function. Nat Cardiovasc Res 1, 691–693 (2022). https://doi.org/10.1038/s44161-022-00115-8

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