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Leveraging FHF modulation to inhibit arrhythmogenic late sodium current

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From Nature Cardiovascular Research

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Fibroblast growth factor homologous factors (FHFs) are an auxiliary subunit of the cardiac voltage-gated sodium channel. We found that FHFs can inhibit the arrhythmogenic late sodium current (INa,L) in an isoform-specific manner, and engineered an FHF-based cell-penetrating peptide that acts as an inhibitor of INa,L and opens avenues for developing future therapeutics.

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Fig. 1: FHFs as potent INa,L inhibitors.

References

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This is a summary of: Chakouri, N. et al. Fibroblast growth factor homologous factors serve as a molecular rheostat in tuning arrhythmogenic cardiac late sodium current. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-022-00060-6 (2022).

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Leveraging FHF modulation to inhibit arrhythmogenic late sodium current. Nat Cardiovasc Res 1, 548–549 (2022). https://doi.org/10.1038/s44161-022-00077-x

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