Rupture or dissection of the aorta is often fatal. Tcheandjieu and colleagues now identify key pathways underlying aortic dilatation, a common prelude to acute aortic events, and assess the utility of a polygenic risk score to identify those at highest risk of aortic death in whom prophylactic surgical repair may be beneficial.
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Gellatly, C., Bown, M.J. Clinical utility of genomic analyses and polygenic risk scores for aortic diseases. Nat Cardiovasc Res 1, 542–543 (2022). https://doi.org/10.1038/s44161-022-00058-0
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DOI: https://doi.org/10.1038/s44161-022-00058-0
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