Coupling an exergonic process with an orthogonal, endergonic one has opened the door to drive artificial systems away from equilibrium. Now, this concept is used to bias the outcome of an uphill chemical reaction.
References
Boekhoven, J., Hendriksen, W. E., Koper, G. J. M., Eelkema, R. & van Esch, J. H. Science 349, 1075–1079 (2015).
Wilson, M. R. et al. Nature 534, 235–240 (2016).
Sangchai, T., Al Shehimy, S., Penocchio, E. & Ragazzon, G. Angew. Chem. Int. Ed. 62, e202309501 (2023).
Bergmann, A. M. et al. Nat. Commun. 14, 6552 (2023).
Borsley, S., Leigh, D. A. & Roberts, B. M. W. J. Am. Chem. Soc. 143, 4414–4420 (2021).
Borsley, S., Kreidt, E., Leigh, D. A. & Roberts, B. M. W. Nature 604, 80–85 (2022).
Anselmi, C., Grininger, M., Gipson, P. & Faraldo-Gómez, J. D. J. Am. Chem. Soc. 132, 12357–12364 (2010).
Olivieri, E., Gallagher, J. M., Betts, A., Mrad, T. W. & Leigh, D. A. Nat. Synth. https://doi.org/10.1038/s44160-024-00493-w (2024).
Hölzl-Hobmeier, A. et al. Nature 564, 240–243 (2018).
Kawamata, Y. et al. J. Am. Chem. Soc. 143, 16580–16588 (2021).
Al Shehimy, S. et al. Preprint at https://doi.org/10.26434/chemrxiv-2024-4krgj (2024).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Stasi, M., Soria-Carrera, H. & Boekhoven, J. Synthesis goes uphill. Nat. Synth (2024). https://doi.org/10.1038/s44160-024-00515-7
Published:
DOI: https://doi.org/10.1038/s44160-024-00515-7
- Springer Nature Limited