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Making selenometabolites nature’s way

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Chemical selenylation of sulfur carrier proteins enables enzymatic incorporation of selenium into small molecules, thereby advancing a biocatalytic method for C–Se bond formation and chemoenzymatic selenometabolite synthesis.

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Fig. 1: Chemical selenylation of sulfur carrier proteins (SCPs) enables enzymatic selenometabolite synthesis.

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Authors and Affiliations

  1. Department of Chemistry, Princeton University, Princeton, NJ, USA

    Chase M. Kayrouz & Mohammad R. Seyedsayamdost

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  1. Chase M. Kayrouz
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  2. Mohammad R. Seyedsayamdost
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Correspondence to Mohammad R. Seyedsayamdost.

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The authors declare no competing interests.

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Kayrouz, C.M., Seyedsayamdost, M.R. Making selenometabolites nature’s way. Nat. Synth 3, 426–427 (2024). https://doi.org/10.1038/s44160-024-00483-y

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