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A photocatalytic method for the regioselective carboxylation of azine C–H bonds using CO2

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The visible-light-driven thiolate-catalysed carboxylation of C(sp2)–H bonds in azines using CO2 is demonstrated. This procedure can be applied to various azine substrates to obtain a range of N-heteroaromatic carboxylic acids with different functionalities, including bioactive molecules and carboxylated N-ligands.

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Fig. 1: Examples of N-heteroaromatic carboxylic acids and a possible mechanism for the visible-light-driven thiolate-catalysed carboxylation of C−H bonds in azines with CO2.

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This is a summary of: Jiang, Y.-X. et al. Visible-light-driven synthesis of N-heteroaromatic carboxylic acids by thiolate-catalysed carboxylation of C(sp²)–H bonds using CO2. Nat. Synth. https://doi.org/10.1038/s44160-023-00465-6 (2024).

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A photocatalytic method for the regioselective carboxylation of azine C–H bonds using CO2. Nat. Synth 3, 305–306 (2024). https://doi.org/10.1038/s44160-023-00466-5

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