Skip to main content
SpringerLink
Log in

Synthesis of large polysaccharides facilitates identification of an active glycan domain

  • Research Briefing
  • Published:

From Nature Synthesis

View current issue Submit your manuscript

A preactivation-based one-pot glycosylation strategy was used to synthesize RN1 — a polysaccharide comprising 140 monosaccharide units isolated from Panax notoginseng, as well as a glycan fragment library. Evaluation of the biological activity of the glycans in vitro revealed that a decasaccharide fragment shows anti-pancreatic cancer activity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Structure and function of RN1 and the active domain.

References

  1. Zeng, P. & Li, J. et al. The structures and biological functions of polysaccharides from traditional Chinese herbs. Prog. Mol. Biol. Transl Sci. 163, 423–444 (2019). This review discusses the functions of polysaccharides from traditional Chinese herbs.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Wang, P. & Zhang, L. et al. An arabinogalactan from flowers of Panax notoginseng inhibits angiogenesis by BMP2/Smad/Id1 signaling. Carbohydr. Polym. 121, 328–335 (2015). This paper reports the isolation of RN1 from Panax notoginseng and its structural characterization.

    Article  CAS  PubMed  Google Scholar 

  3. Zhang, L. & Wang, P. et al. A novel galectin-3 inhibitor, inhibits pancreatic cancer cell growth in vitro and in vivo via blocking galectin-3 associated signaling pathways. Oncogene 36, 1297–1308 (2017). This paper reports the biological activity of isolated RN1 and the possible mechanism of its anti-pancreatic cancer activity.

    Article  PubMed  Google Scholar 

  4. Huang, X. & Huang, L. et al. Iterative one-pot synthesis of oligosaccharides. Angew. Chem. Int. Ed. 43, 5221–5224 (2004). This paper reports the preactivation-based one-pot glycosylation strategy that we used herein and demonstrates its application in oligosaccharide assembly.

    Article  CAS  Google Scholar 

Download references

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This is a summary of: Qin, X. et al. Synthesis of branched arabinogalactans up to a 140-mer from Panax notoginseng and their anti-pancreatic-cancer activity. Nat. Synth. https://doi.org/10.1038/s44160-023-00428-x (2023).

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Synthesis of large polysaccharides facilitates identification of an active glycan domain. Nat. Synth 3, 158–159 (2024). https://doi.org/10.1038/s44160-023-00430-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s44160-023-00430-3

  • Springer Nature Limited

Search

Navigation