Palladium-catalysed dicarbonylation using two different nucleophiles enables the selective synthesis of unsymmetrical diamides and amido esters in a single step.
This is a preview of subscription content, log in via an institution to check access.
References
Constable, D. J. C. et al. Green Chem. 9, 41–1420 (2007).
Beller, M. & Wu, X.-F. Transition Metal Catalyzed Carbonylation Reactions: Carbonylative Activation of C–X Bonds (Springer, 2013).
Ge, Y. et al. Nat. Synth. https://doi.org/10.1038/s44160-023-00411-6 (2023).
Beller, M. et al. in Applied Homogeneous Catalysis with Organometallic Compounds: A Comprehensive Handbook in Four Volumes (eds Cornils, B. et al) 91–190 (Wiley-VCH Verlag GmbH & Co. KGaA, 2017).
Zhu, C., Yang, B. & Bäckvall, J.-E. J. Am. Chem. Soc. 137, 11868–11871 (2015).
Torres, G. M., Quesnel, J. S., Bijou, D. & Arndtsen, B. J. Am. Chem. Soc. 138, 7315–7324 (2016).
Ge, Y. et al. JACS Au 1, 1257–1265 (2021).
Rees, D. C., Congreve, M., Murray, C. W. & Carr, R. Nat. Rev. Drug. Discov. 3, 660–672 (2004).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Zgheib, J., Arndtsen, B.A. Two nucleophiles take turns. Nat. Synth 3, 148–149 (2024). https://doi.org/10.1038/s44160-023-00393-5
Published:
Issue Date:
DOI: https://doi.org/10.1038/s44160-023-00393-5
- Springer Nature Limited