Converting simple building blocks into enantiopure amines is an important synthetic transformation. Now, a biocatalyst has been discovered that catalyses two reductive steps within a single active site, and can synthesize a range of amine targets from ene–one starting materials.
References
Fryszkowska, A. & Devine, P. N. Curr. Opin. Chem. Biol. 55, 151–160 (2020).
Wu, S., Snajdrova, R., Moore, J. C., Baldenius, K. & Bornscheuer, U. T. Angew. Chem. Int. Ed. 60, 88–119 (2021).
Arnold, F. H. Angew. Chem. Int. Ed. 58, 14420–14426 (2019).
Thorpe, T. W. et al. Nature 604, 86–91 (2022).
Marshall, J. R. et al. Nat. Chem. 13, 140–148 (2021).
Crawshaw, R. et al. Nat. Chem. 14, 313–320 (2022).
Zetzsche, L. E. et al. Nature 603, 79–85 (2022).
Bell, E. L. et al. Nat. Rev. Methods Primers 1, 46 (2021).
Huffman, M. A. et al. Science 66, 1255–1259 (2019).
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Herrera, M.A., Campopiano, D.J. Buy one, get one free. Nat. Synth 1, 420–421 (2022). https://doi.org/10.1038/s44160-022-00092-7
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DOI: https://doi.org/10.1038/s44160-022-00092-7
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