Skip to main content
SpringerLink
Log in

Reproductive aging

Sertoli cell lysosomes and late-onset hypogonadism

  • News & Views
  • Published:

From Nature Aging

View current issue Submit your manuscript

Zhou and colleagues explore reversing testicular aging and late-onset hypogonadism by targeting lysosomal function in Sertoli cells. The aging-related transformation of Sertoli cells into a lipid-hoarding subtype with dysregulated phagolysosomes and autolysosomes was reversed using the TRPML channel agonist ML-SA1, which demonstrates the potential of this targeted therapy in alleviating testosterone decline and systemic male-aging phenotypes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: ML-SA1 induced rejuvenation in testicular dysfunction and LOH.

References

  1. Deng, Z. et al. Nat Aging https://doi.org/10.1038/s43587-024-00614-2 (2024).

    Article  PubMed  Google Scholar 

  2. França, L. R., Hess, R. A., Dufour, J. M., Hofmann, M. C. & Griswold, M. D. Andrology 4, 189–212 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Mruk, D. D. & Cheng, C. Y. Endocr. Rev. 25, 747–806 (2004).

    Article  CAS  PubMed  Google Scholar 

  4. Alves, M. G. et al. Cell. Mol. Life Sci. 70, 777–793 (2013).

    Article  CAS  PubMed  Google Scholar 

  5. Carrageta, D. F., Oliveira, P. F., Alves, M. G. & Monteiro, M. P. Obes. Rev. 20, 1148–1158 (2019).

    Article  PubMed  Google Scholar 

  6. Chaudhuri, G. R. et al. Middle East Fertil. Soc. J. 27, 8 (2022).

    Article  Google Scholar 

  7. Fui, M. N. T., Dupuis, P. & Grossmann, M. Asian J. Androl. 16, 223–231 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Grossmann, M. & Matsumoto, A. M. J. Clin. Endocrinol. Metab. 102, 1067–1075 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Khera, M. et al. Mayo Clin. Proc. 91, 908–926 (2016).

    Article  PubMed  Google Scholar 

  10. Rhoden, E. L. & Morgentaler, A. N. Engl. J. Med. 350, 482–492 (2004).

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

We gratefully acknowledge grants from National Council for Scientific and Technological Development (CNPq-Brazil) (no. 402973/2022-4); and Brazilian Federal Agency for Support and Evaluation of Graduate Education (CAPES-Brazil), CAPES-PrInt, no. Finance Code 001. We also acknowledge the Portuguese Foundation for Science and Technology for funding to iBiMED (UIDP/04501/2020 and UIDB/04501/2020) and LAQVREQUIMTE (UIDB/50006/2020), co-funded by FEDER funds through the COMPETE/QREN, FSE/POPH, and POCI—COMPETE 2020 (POCI-01-0145-FEDER- 007491) funds.

Author information

Authors and Affiliations

  1. Department of Biochemistry, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil

    Ariane Zamoner

  2. LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Aveiro, Portugal

    Pedro Fontes Oliveira

  3. Department of Medical Sciences, Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal

    Marco G. Alves

Authors
  1. Ariane Zamoner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pedro Fontes Oliveira
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Marco G. Alves
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Ariane Zamoner, Pedro Fontes Oliveira or Marco G. Alves.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zamoner, A., Oliveira, P.F. & Alves, M.G. Sertoli cell lysosomes and late-onset hypogonadism. Nat Aging 4, 618–620 (2024). https://doi.org/10.1038/s43587-024-00622-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s43587-024-00622-2

  • Springer Nature America, Inc.

Search

Navigation