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Compromised biogenesis of DHEA-S is implicated in primate adrenal aging

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After discovering the sensitivity of the adrenal zona reticularis region to aging, we found that low-density lipoprotein receptor (LDLR) deficiency hampers both cholesterol uptake and dehydroepiandrosterone sulfate (DHEA-S) production. This finding reveals the cellular basis for age-related adrenal insufficiency and provides insights for the development of interventions to delay endocrine and systemic aging.

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Fig. 1: Cellular and molecular changes in primate adrenal aging.

References

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Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This is a summary of: Wang, Q. et al. Aging induces region-specific dysregulation of hormone synthesis in the primate adrenal gland. Nat. Aging, https://doi.org/10.1038/s43587-024-00588-1 (2024).

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Compromised biogenesis of DHEA-S is implicated in primate adrenal aging. Nat Aging 4, 291–292 (2024). https://doi.org/10.1038/s43587-024-00601-7

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