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Blood protein markers predict 15-year risk of dementia

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Using a data-driven proteomics strategy from a prospective community-based cohort with long-term follow-up, this study reports that plasma levels of glial fibrillary acidic protein (GFAP) can predict the risk of dementia, even 15 years before disease diagnosis. Our findings have important implications for early screening and interventions for dementia.

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Fig. 1: Predictive performance and temporal trajectories of plasma proteins.

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This is a summary of: Guo, Y. et al. Plasma proteomic profiles predict future dementia in healthy adults. Nat. Aging https://doi.org/10.1038/s43587-023-00565-0 (2024).

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Blood protein markers predict 15-year risk of dementia. Nat Aging 4, 173–174 (2024). https://doi.org/10.1038/s43587-023-00566-z

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