Tagmentation-based methylation sequencing (TIME-seq) is an efficient and cost-effective solution for measuring and generating epigenetic clocks. We applied TIME-seq to over 2,800 mouse and human DNA samples to produce clocks that demonstrate accuracy and robustness; the method also outperforms conventional methods in speed and cost. The simple and practical design of TIME-seq facilitates large-scale epigenetic clock analysis, which makes it a valuable tool for advancing aging research.
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This is a summary of: Griffin, P. T. et al. TIME-seq reduces time and cost of DNA methylation measurement for epigenetic clock construction. Nat. Aging, https://doi.org/10.1038/s43587-023-00555-2 (2024).
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Efficient epigenetic clock measurements with TIME-seq. Nat Aging 4, 175–176 (2024). https://doi.org/10.1038/s43587-023-00559-y
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DOI: https://doi.org/10.1038/s43587-023-00559-y
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