In vivo reprogramming by expression of the transcription factors OCT4, SOX2, KLF4, and MYC (OSKM factors) has been associated with early mortality and cancer. We report that these adverse effects are associated with liver and intestinal dysfunction. Strategic control of OSKM expression in these organs through a newly developed transgenic mouse model reduced adverse effects. Our model yields valuable insights into the potential of in vivo reprogramming for rejuvenation and regeneration.
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References
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This is a summary of: Parras, A. et al. In vivo reprogramming leads to premature death linked to hepatic and intestinal failure. Nat. Aging https://doi.org/10.1038/s43587-023-00528-5 (2023).
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In vivo reprogramming that spares the liver and intestine shows reduced toxicity in mice. Nat Aging 3, 1484–1485 (2023). https://doi.org/10.1038/s43587-023-00533-8
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DOI: https://doi.org/10.1038/s43587-023-00533-8
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