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Alzheimer’s disease

Tangles, not TANGO: targeting tau aggregates

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Targeting tau in addition to amyloid-β could be the next phase of disease modification in Alzheimer’s disease. The TANGO trial of gosuranemab, which binds the tau N terminus, affected neither clinical outcomes nor brain levels of aggregated tau. The results highlight the importance and challenge of reducing aggregated tau.

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Fig. 1: Gosuranemab was safe and tolerable, and bound tau monomers, but did not affect tau PET.

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Authors and Affiliations

  1. Brigham and Women’s Hospital, Boston, MA, USA

    Andrew M. Stern & Reisa A. Sperling

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  1. Andrew M. Stern
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  2. Reisa A. Sperling
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Correspondence to Andrew M. Stern.

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Competing interests

A.M.S. receives research support from the following grants: K08 NS128329 and the Alzheimer’s Association. R.A.S. has served as a paid consultant for AC Immune, Alector, Acumen, Bristol Myers Squibb, Genentech, NervGen, Oligomerix, Prothena, Renew, Vigil Neuroscience, Ionis and Vaxxinity. She receives research support from Eisai and Eli Lilly as part of public–private partnership clinical trials, and also receives research support from the following grants: P01 AG036694, U24 AG057437, R01 AG063689, R01 AG054029, R01 AG053798, GHR Foundation, National Institute on Aging, Fidelity Biosciences, and the Alzheimer’s Association.

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Stern, A.M., Sperling, R.A. Tangles, not TANGO: targeting tau aggregates. Nat Aging 3, 1472–1473 (2023). https://doi.org/10.1038/s43587-023-00526-7

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