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Dopaminergic and noradrenergic nuclei relate to different memory types in older adults

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By using multimodal MRI in aging humans, we found that noradrenergic brain regions are associated with episodic memory impairment, whereas dopaminergic areas are implicated in working memory impairment. Unravelling the role of changes in these neurotransmitter systems in age-related memory loss contributes to our understanding of the development of neurodegenerative diseases.

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Fig. 1: Multimodal MRI-based integrity estimates of noradrenergic and dopaminergic nuclei are associated with late-life memory.

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This is a summary of: Dahl, M. J. et al. The integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance. Nat. Aging https://doi.org/10.1038/s43587-023-00469-z (2023).

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Dopaminergic and noradrenergic nuclei relate to different memory types in older adults. Nat Aging 3, 1051–1052 (2023). https://doi.org/10.1038/s43587-023-00497-9

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