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Dissecting microglial aging and creating a model of aged microglia in a non-aged brain

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Microglia exhibit unexpected sex differences in gene expression and accessibility and compromised inflammatory responses during the aging process in mice. We established a mouse model with accelerated microglial turnover (3xDR), which results in aged microglia in non-aged brains. Analysis of this model revealed that aged microglia themselves contribute to cognitive decline.

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Fig. 1: Microglia exhibit sex differences during the aging process.

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This is a summary of: Li, X. et al. Transcriptional and epigenetic decoding of the microglial aging process. Nat. Aging https://doi.org/10.1038/s43587-023-00479-x (2023).

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Dissecting microglial aging and creating a model of aged microglia in a non-aged brain. Nat Aging 3, 1185–1186 (2023). https://doi.org/10.1038/s43587-023-00487-x

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