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Moderately cold temperatures prevent protein aggregation related to aging and disease

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Moderately cold temperatures trigger the removal of aggregation-prone proteins in the invertebrate model Caenorhabditis elegans and cultured human cells, preventing the accumulation of pathological aggregates linked with age-related neurodegenerative disorders such as amyotrophic lateral sclerosis and Huntington’s disease.

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Fig. 1: Moderate cold temperature induces trypsin-like proteasome activity in C. elegans and human cells.

References

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This is a summary of: Lee, H. J. et al. Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes. Nat. Aging https://doi.org/10.1038/s43587-023-00383-4 (2023).

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Moderately cold temperatures prevent protein aggregation related to aging and disease. Nat Aging 3, 479–480 (2023). https://doi.org/10.1038/s43587-023-00397-y

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