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A senolytic strategy integrating multiple technologies delays aging

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Cellular senesence is believed to be a driver of aging. We designed and synthesized a photosensitive prodrug that destroys senescent cells by integrating multiple technologies that combine biomarker guidance with a fluorescence tag, target-site anchoring and photodynamic therapy, providing a strategy for monitoring and specifically eliminating senescent cells to regulate aging.

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Fig. 1: Selective clearance of SnCs.

References

  1. Zhu, Y. et al. The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell 14, 644–658 (2015). This paper reports the combination of dasatinib and quercetin as a senolytic drug.

  2. Xu, M. et al. Senolytics improve physical function and increase lifespan in old age. Nat. Med. 24, 1246–1256 (2018). This paper reports that transplanting SnCs into young mice causes persistent physical dysfunction, which can be alleviated by senolytic drugs.

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This is a summary of: Shi, D. et al. Photoactivatable senolysis with single-cell resolution delays aging. Nat. Aging https://doi.org/10.1038/s43587-023-00360-x (2023).

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A senolytic strategy integrating multiple technologies delays aging. Nat Aging 3, 244–245 (2023). https://doi.org/10.1038/s43587-023-00369-2

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