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Landscape of somatic mutations in aging human heart muscle cells

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Using single-cell whole-genome sequencing, we identified and characterized the landscape of somatic single-nucleotide variants (sSNVs) in single cardiomyocytes from individuals across the human lifespan. Aged cardiomyocytes were found to have a higher burden of sSNVs and show mutational signatures that suggest failed repair of oxidative DNA damage.

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Fig. 1: sSNVs in the aging heart.

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This is a summary of: Choudhury, S. et al. Somatic mutations in single human cardiomyocytes reveal age-associated DNA damage and widespread oxidative genotoxicity. Nat. Aging https://doi.org/10.1038/s43587-022-00261-5 (2022).

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Landscape of somatic mutations in aging human heart muscle cells. Nat Aging 2, 686–687 (2022). https://doi.org/10.1038/s43587-022-00264-2

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