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Tumor immunology

γδ T cells as unconventional targets of checkpoint blockade

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Identifying which patients will benefit most from immune checkpoint blockade (ICB) is an important clinical challenge. A study now finds that Vδ1+ γδ T cells are associated with better response to ICB in melanoma tumors with a lower neoantigen load and shows that some effector functions of PD-1+ Vδ1+ T cells are repressed after engagement of PD-1 by PD-L1.

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Fig. 1: Conventional and unconventional actions of ICB.

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Authors and Affiliations

  1. Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Hans R. Widlund

  2. Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Lydia Lynch

Authors
  1. Hans R. Widlund
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  2. Lydia Lynch
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Correspondence to Lydia Lynch.

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The authors declare no competing interests.

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Widlund, H.R., Lynch, L. γδ T cells as unconventional targets of checkpoint blockade. Nat Cancer 5, 373–374 (2024). https://doi.org/10.1038/s43018-024-00735-y

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