Our study reveals that the LGR4–Wnt signaling pathway dictates both ferroptosis and stemness traits to confer drug resistance to tumor cells. We thus generated a monoclonal antibody against LGR4 that blocks LGR4–Wnt signaling and sensitizes chemotherapy-resistant colorectal cancer tumors via selective promotion of ferroptosis.
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This is a summary of: Zheng, H. et al. Targeted activation of ferroptosis in colorectal cancer via LGR4 targeting overcomes acquired drug resistance. Nat. Cancer https://doi.org/10.1038/s43018-023-00715-8 (2024).
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Targeting LGR4–Wnt activates ferroptosis and reverses drug resistance in colorectal cancer. Nat Cancer 5, 542–543 (2024). https://doi.org/10.1038/s43018-023-00714-9
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DOI: https://doi.org/10.1038/s43018-023-00714-9
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