Real-world data (RWD) and real-world evidence (RWE) from heterogeneous data sources has the potential to transform oncology research, especially when coupled with artificial intelligence (AI). We discuss the issues involved in primary data capture and post-hoc AI analysis and propose using AI to support the capture of primary RWD.
References
Raoof, S. & Kurzrock, R. Sci. Transl. Med. 14, eabn6911 (2022).
Swanson, K., Wu, E., Zhang, A., Alizadeh, A. A. & Zou, J. Cell 186, 1772–1791 (2023).
NIH National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/study/NCT04921553 (2021).
Bartlett, V. L., Dhruva, S. S., Shah, N. D., Ryan, P. & Ross, J. S. JAMA Netw. Open 2, e1912869 (2019).
Soni, P. D. et al. J. Clin. Oncol. 37, 1209–1216 (2019).
Sieswerda, M. et al. JCO Clin. Cancer Inform. 7, e2200080 (2023).
Pearl, J. Causality 2nd edn (Cambridge Univ. Press, 2009).
Wang, S. V. et al. JAMA 329, 1376–1385 (2023).
Wallach, J. D. et al. JAMA Netw. Open 4, e2133667 (2021).
Goodman, S. N., Schneeweiss, S. & Baiocchi, M. JAMA 317, 705–707 (2017).
Overhage, J. M. & McCallie, D. Physician Time Spent Using the Electronic Health Record During Outpatient Encounters: A Descriptive Study. Ann. Intern. Med. 172, 169–174 (2020).
Arndt, B. G. et al. Ann. Fam. Med. 15, 419–426 (2017).
van Buchem, M. M. et al. npj Digit. Med. 4, 57 (2021).
Nguyen, O. T. et al. JCO Clin. Cancer Inform. 7, e2200166 (2023).
Ciecierski-Holmes, T., Singh, R., Axt, M., Brenner, S. & Barteit, S. npj Digit. Med. 5, 162 (2022).
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Mahon, P., Hall, G., Dekker, A. et al. Harnessing oncology real-world data with AI. Nat Cancer 4, 1627–1629 (2023). https://doi.org/10.1038/s43018-023-00689-7
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DOI: https://doi.org/10.1038/s43018-023-00689-7
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