Skip to main content
Log in

Transmissible cancer

A deep dive into transmissible cancer evolution in bivalve mollusks

  • News & Views
  • Published:

From Nature Cancer

View current issue Submit your manuscript

Transmissible cancer affects marine bivalve mollusks worldwide, but how genetic mechanisms influence cancer evolution and disease spread remains largely unexplored. Two new studies provide insights into the ancient origin of founder clones and the long-term tolerance of contagious cancer cells to extreme genome instability.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1: Transmissible cancer in bivalve mollusks is characterized by long-term tolerance of nuclear and mitochondrial genome instability.

References

  1. Murgia, C., Pritchard, J. K., Kim, S. Y., Fassati, A. & Weiss, R. A. Cell 126, 477–487 (2006).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Pye, R. J. et al. Proc. Natl Acad. Sci. USA 113, 374–379 (2016).

    Article  CAS  PubMed  Google Scholar 

  3. Metzger, M. J., Reinisch, C., Sherry, J. & Goff, S. P. Cell 161, 255–263 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Yonemitsu, M. A. et al. eLife 8, e47788 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Carballal, M. J., Barber, B. J., Iglesias, D. & Villalba, A. J. Invertebr. Pathol. 131, 83–106 (2015).

    Article  PubMed  Google Scholar 

  6. Bruzos, A. L. et al. Nat. Cancer https://doi.org/10.1038/s43018-023-00641-9 (2023).

    Article  PubMed  Google Scholar 

  7. Hart, S. F. M. et al. Nat. Cancer https://doi.org/10.1038/s43018-023-00643-7 (2023).

    Article  PubMed  Google Scholar 

  8. Kumar, S., Stecher, G., Suleski, M. & Hedges, S. B. Mol. Biol. Evol. 34, 1812–1819 (2017).

    Article  CAS  PubMed  Google Scholar 

  9. Fu, D., Calvo, J. A. & Samson, L. D. Nat. Rev. Cancer 12, 104–120 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Murchison, E. P. et al. Science 343, 437–440 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Stammnitz, M. R. et al. Science 380, 283–293 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Murchison, E. P. et al. Cell 148, 780–791 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Hanahan, D. Cancer Discov. 12, 31–46 (2022).

    Article  CAS  PubMed  Google Scholar 

  14. Strakova, A. et al. Nat. Commun. 11, 3059 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. FAO. https://doi.org/10.4060/cc0461en (2022).

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Andreas Bergthaler.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Schönbichler, A., Bergthaler, A. A deep dive into transmissible cancer evolution in bivalve mollusks. Nat Cancer 4, 1528–1530 (2023). https://doi.org/10.1038/s43018-023-00655-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s43018-023-00655-3

  • Springer Nature America, Inc.

Navigation