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Cancer cachexia

Endothelium directs fat remodeling in cachexia

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Certain cancers disrupt metabolism, leading to the wasting syndrome known as cachexia. How tumor-induced mediators of cachexia induce changes in end organs is unclear. A study implicates the endothelium as an amplifier of tumor signals in fat, in which NOTCH1 promotes adipose tissue remodeling via retinoic acid, IL-33 and IGFBP3.

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Fig. 1: NOTCH1 activity in the endothelium regulates the adipose tissue microenvironment in cancer cachexia.

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Authors and Affiliations

  1. Department of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, OR, USA

    Brittany R. Counts & Teresa A. Zimmers

  2. Knight Cancer Institute, Portland, OR, USA

    Teresa A. Zimmers

  3. Portland Veterans Administration Medical Center, Portland, OR, USA

    Teresa A. Zimmers

Authors
  1. Brittany R. Counts
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  2. Teresa A. Zimmers
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Correspondence to Teresa A. Zimmers.

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Competing interests

T.A.Z. serves or has previously served on advisory boards and/or as a scientific advisory board member for PeleOS Technologies, LLC; Emmyon, Inc; Aveo; and Immuneering.

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Counts, B.R., Zimmers, T.A. Endothelium directs fat remodeling in cachexia. Nat Cancer 4, 1531–1533 (2023). https://doi.org/10.1038/s43018-023-00644-6

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