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Cancer immunotherapy

CD4+ CAR T cells — more than helpers

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Therapeutic products containing CD8+ and CD4+ T cells expressing CARs are effective at inducing remission in patients with cancer. How CD4+ CAR T cells contribute to the anti-tumor response has not been well established. A study uses syngeneic models and in vivo imaging to glean mechanistic insights into how CD4+ T cells target tumors.

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Fig. 1: CD4+ CAR T cells target tumors using multiple mechanisms.

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Authors and Affiliations

  1. Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

    M. Eric Kohler & Terry J. Fry

  2. Center for Cancer and Blood Disorders, Children’s Hospital Colorado, Aurora, CO, USA

    M. Eric Kohler & Terry J. Fry

Authors
  1. M. Eric Kohler
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  2. Terry J. Fry
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Correspondence to M. Eric Kohler.

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The authors declare no competing interests.

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Kohler, M.E., Fry, T.J. CD4+ CAR T cells — more than helpers. Nat Cancer 4, 928–929 (2023). https://doi.org/10.1038/s43018-023-00567-2

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  • DOI: https://doi.org/10.1038/s43018-023-00567-2

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